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Friday, October 2, 2026The Morning Brief →Sign in
XPHSPDRINDEX

SPDR S&P Pharmaceuticals ETF

$63.78-1.88% vs prior close
477452-WK

Price through Oct 1 · Flows through Sep 30. Figures use the latest available records, not a live quote. Fund details retrieved Oct 1. Holdings snapshot retrieved Oct 1.

In seeking to track the performance of the S&P Pharmaceuticals Select Industry Index (the "index"), the fund employs a sampling strategy. It generally invests substantially all, but at least 80%, of its total assets in the securities comprising the index. The index represents the pharmaceuticals segment of the S&P Total Market Index ("S&P TMI").

Price & daily flows
68.360.753.163.78DAILY NET FLOWOct 1Jan 30Jun 1Oct 1

SOURCE: MARKET TAPE & DAILY CREATION/REDEMPTION RECORDS · 3Y SHOWN · NET +$218M OVER THIS RANGE

The desk’s read

Money is leaving — −$15M in net outflows over the past month, about 2.9% of the fund's asset base, while the price has returned +13.9% so far this year. At 0.35% a year it is not the cheapest way in — AVIE has a reported fee of 0.25%.

COMPOSED FROM THE FUND’S OWN DAILY RECORDS · UPDATED WITH EACH REFRESH

$524Massets under management
0.35%expense ratio · $35 per $10,000 a year
−$15Mnet flow, trailing month
170Kavg daily volume, 30 days
41holdings · US-domiciled
2006listed June 19, 2006 · beta 0.78
The book at a glance
AMLX-3.5%MBX-3.5%OMER-3.0%DFTX-1.2%CORT-1.0%AMRX-0.3%MANE-3.3%PRGO-5.0%ELVN+0.8%TARS-4.0%EWTX-0.3%ETON+1.0%LGND-3.1%NUVB-0.7%MRK-1.0%HRMY+0.8%VTRS-1.5%BMY-1.5%PFE-1.4%JNJ-2.3%MAZE-1.9%PCRX-0.2%XERS-3.2%TRVI-1.0%RPRX-1.3%AMPH-1.8%OGN+0.1%JAZZ+0.6%LLY-0.6%PAHC+0.4%ELAN-2.8%SUPN-2.0%INDV-1.3%PBH-2.4%INVA-3.1%ANIP+0.4%HROW-0.6%ZTS-1.0%OCUL-5.0%NKTR-22.4%

CELL SIZE IS PORTFOLIO WEIGHT · COLOR IS THE CHANGE IN THE LATEST AVAILABLE SNAPSHOT · TOP 40 POSITIONS

HoldingsDownload CSV
#HoldingWeightPriceDay52-wk
1AMLXAMYLYX PHARMACEUTICALS2.04%$28.08-3.5%
2MBXMBX Biosciences2.72%$56.55-3.5%
3OMEROMEROS1.42%$18.47-3.0%
4DFTXDefinium Therapeutics3.09%$37.60-1.2%
5CORTCORCEPT THERAPEUTICS1.70%$114.03-1.0%
6AMRXAMNEAL PHARMACEUTICALS1.72%$20.07-0.3%
7MANEVERADERMICS INC2.02%$117.22-3.3%
8PRGOPERRIGO CO1.42%$14.02-5.0%
9ELVNENLIVEN THERAPEUTICS2.09%$46.21+0.8%
10TARSTARSUS PHARMACEUTICALS1.57%$75.46-4.0%
11EWTXEDGEWISE THERAPEUTICS1.88%$40.48-0.3%
12ETONETON PHARMACEUTICALS1.30%$51.98+1.0%
13LGNDLIGAND PHARMACEUTICALS1.94%$302.74-3.1%
14NUVBNUVATION BIO1.89%$5.56-0.7%
15MRKMERCK & CO1.65%$143.81-1.0%

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Sector weights
Healthcare100%
Health Technology99.68%
Other0.33%
Mutual fund0.32%
PORTFOLIO COMPOSITION, LATEST DISCLOSURE
Country weights
United States99.6%
Ireland9.31%
Singapore0.4%
Cayman Islands0.39%
PORTFOLIO COMPOSITION, LATEST DISCLOSURE
Performance
1 week-3.5%
1 month-9.0%
3 months-2.4%
6 months+24.2%
YTD+13.9%
1 year+31.4%
3 years—

PRICE RETURN, DISTRIBUTIONS NOT REINVESTED

Net flows
1 week−$13M
1 month−$15M
3 months+$115M
YTD+$252M
1 year+$274M

CREATION/REDEMPTION DOLLARS, DAILY RECORDS

Monthly net flows
OctNovDecJanFebMarAprMayJunJulAugSep
DAILY CREATION/REDEMPTION RECORDS, TRAILING TWELVE MONTHS
The risk read
23%realized volatility, 30 days (annualized)
23%realized volatility, 1 year
-13.9%deepest fall from a peak, 1 year
-13.9%latest close versus that peak

The top holding is 3.1% of the book; the top ten carry 22%. Spread across 66+ names, it behaves like roughly 60 equally-weighted positions.

VOLATILITY & DRAWDOWN FROM THE DAILY TAPE · CONCENTRATION FROM THE LATEST DISCLOSED BOOK

Options tape
—calls · latest snapshot
—puts · latest snapshot
—put/call ratio
583Kshares traded
Most-traded holdings, options premiumBullishBearish
LLY ELI LILLY$30M$32M
LQDA LIQUIDIA$13M$17M
JNJ JOHNSON & JOHNSON$3M$3M
MRK MERCK & CO$3M$2M
NKTR NEKTAR THERAPEUTICS$2M$2M

TODAY’S OPTIONS PREMIUM IN THE FUND’S UNDERLYING NAMES

The case against XPH

Due diligence cuts both ways. These funds sit on the same shelf and beat XPH on at least one dimension that matters — the fee, the asset base, or where the money is going.

FundFeeAssetsFlow, 1MThe case
SPDW State Street SPDR Portfolio Developed World ex-US ETF0.03%$41.5B+$286M-32bp on fee · 79× the assets · +$286M in over the monthHead-to-head
SPMD State Street SPDR Portfolio S&P 400 Mid Cap ETF0.03%$18.2B+$199M-32bp on fee · 35× the assets · +$199M in over the monthHead-to-head
IDEV iShares Core MSCI International Developed Markets ETF0.04%$32.9B+$497M-31bp on fee · 63× the assets · +$497M in over the monthHead-to-head
IGSB iShares 1-5 Year Investment Grade Corporate Bond ETF0.04%$23.7B+$575M-31bp on fee · 45× the assets · +$575M in over the monthHead-to-head
IGIB iShares 5-10 Year Investment Grade Corporate Bond ETF0.04%$18.6B+$412M-31bp on fee · 35× the assets · +$412M in over the monthHead-to-head
Sign in to save this to The RecordA timestamped copy for the file — documentation, not advice.
InstrumentsHarvest substitutesTrade cost at $1MClient tearsheetStress this fund
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