SBIOALPS FundsACTIVE
ALPS Medical Breakthroughs ETF
$54.55-0.04% vs prior close
427152-WK
Price through Oct 22, 2026 · Flows through unavailable. Figures use the latest available records, not a live quote. Fund details retrieved Oct 22, 2026. Holdings snapshot retrieved Oct 22, 2026.
The fund employs a "passive management" - or indexing - investment approach designed to track the performance of the underlying index. It will normally invest at least 80% of its net assets in securities that comprise the underlying index. The underlying index is comprised of small and mid-cap stocks of biotechnology companies that have one or more drugs in either Phase II or Phase III of the U.S. Food and Drug Administration clinical trials.
SBIO price
Source: Market tape, daily closes; price return, distributions not reinvested
Table
| Date | SBIO close |
|---|---|
| Oct 22, 2025 | $42.03 |
| Oct 23, 2025 | $42.07 |
| Oct 24, 2025 | $42.48 |
| Oct 27, 2025 | $44.38 |
| Oct 28, 2025 | $44.64 |
| Oct 29, 2025 | $44.22 |
| Oct 30, 2025 | $44.70 |
| Oct 31, 2025 | $45.13 |
| Nov 3, 2025 | $43.95 |
| Nov 4, 2025 | $43.65 |
| Nov 5, 2025 | $43.74 |
| Nov 6, 2025 | $44.27 |
| Nov 7, 2025 | $44.13 |
| Nov 10, 2025 | $44.44 |
| Nov 11, 2025 | $46.07 |
| Nov 12, 2025 | $46.19 |
| Nov 13, 2025 | $45.27 |
| Nov 14, 2025 | $46.11 |
| Nov 17, 2025 | $46.64 |
| Nov 18, 2025 | $46.80 |
| Nov 19, 2025 | $46.59 |
| Nov 20, 2025 | $46.08 |
| Nov 21, 2025 | $47.05 |
| Nov 24, 2025 | $48.22 |
| Nov 25, 2025 | $48.87 |
| Nov 26, 2025 | $49.85 |
| Nov 28, 2025 | $49.91 |
| Dec 1, 2025 | $48.43 |
| Dec 2, 2025 | $47.70 |
| Dec 3, 2025 | $49.51 |
| Dec 4, 2025 | $50.15 |
| Dec 5, 2025 | $50.45 |
| Dec 8, 2025 | $51.62 |
| Dec 9, 2025 | $50.53 |
| Dec 10, 2025 | $50.81 |
| Dec 11, 2025 | $51.09 |
| Dec 12, 2025 | $51.25 |
| Dec 15, 2025 | $50.85 |
| Dec 16, 2025 | $50.42 |
| Dec 17, 2025 | $49.71 |
| Dec 18, 2025 | $49.62 |
| Dec 19, 2025 | $51.16 |
| Dec 22, 2025 | $52.19 |
| Dec 23, 2025 | $51.86 |
| Dec 24, 2025 | $52.90 |
| Dec 26, 2025 | $52.20 |
| Dec 29, 2025 | $51.32 |
| Dec 30, 2025 | $50.79 |
| Dec 31, 2025 | $51.22 |
| Jan 2, 2026 | $50.16 |
| Jan 5, 2026 | $48.96 |
| Jan 6, 2026 | $49.18 |
| Jan 7, 2026 | $51.45 |
| Jan 8, 2026 | $50.57 |
| Jan 9, 2026 | $51.37 |
| Jan 12, 2026 | $50.95 |
| Jan 13, 2026 | $50.86 |
| Jan 14, 2026 | $52.48 |
| Jan 15, 2026 | $51.22 |
| Jan 16, 2026 | $51.07 |
| Jan 20, 2026 | $51.97 |
| Jan 21, 2026 | $52.98 |
| Jan 22, 2026 | $54.18 |
| Jan 23, 2026 | $52.55 |
| Jan 26, 2026 | $52.52 |
| Jan 27, 2026 | $53.05 |
| Jan 28, 2026 | $51.94 |
| Jan 29, 2026 | $52.36 |
| Jan 30, 2026 | $51.25 |
| Feb 2, 2026 | $52.51 |
| Feb 3, 2026 | $52.44 |
| Feb 4, 2026 | $51.32 |
| Feb 5, 2026 | $48.92 |
| Feb 6, 2026 | $50.99 |
| Feb 9, 2026 | $51.17 |
| Feb 10, 2026 | $51.41 |
| Feb 11, 2026 | $50.61 |
| Feb 12, 2026 | $50.29 |
| Feb 13, 2026 | $49.72 |
| Feb 17, 2026 | $50.40 |
| Feb 18, 2026 | $50.61 |
| Feb 19, 2026 | $51.11 |
| Feb 20, 2026 | $50.91 |
| Feb 23, 2026 | $51.73 |
| Feb 24, 2026 | $52.63 |
| Feb 25, 2026 | $52.23 |
| Feb 26, 2026 | $52.06 |
| Feb 27, 2026 | $51.55 |
| Mar 2, 2026 | $50.88 |
| Mar 3, 2026 | $49.48 |
| Mar 4, 2026 | $50.72 |
| Mar 5, 2026 | $49.41 |
| Mar 6, 2026 | $49.86 |
| Mar 9, 2026 | $51.29 |
| Mar 10, 2026 | $51.88 |
| Mar 11, 2026 | $51.70 |
| Mar 12, 2026 | $50.18 |
| Mar 13, 2026 | $49.81 |
| Mar 16, 2026 | $50.67 |
| Mar 17, 2026 | $50.69 |
| Mar 18, 2026 | $49.08 |
| Mar 19, 2026 | $49.47 |
| Mar 20, 2026 | $48.33 |
| Mar 23, 2026 | $48.85 |
| Mar 24, 2026 | $48.16 |
| Mar 25, 2026 | $50.00 |
| Mar 26, 2026 | $49.90 |
| Mar 27, 2026 | $48.36 |
| Mar 30, 2026 | $48.05 |
| Mar 31, 2026 | $52.34 |
| Apr 1, 2026 | $52.86 |
| Apr 2, 2026 | $53.49 |
| Apr 6, 2026 | $53.56 |
| Apr 7, 2026 | $53.78 |
| Apr 8, 2026 | $54.35 |
| Apr 9, 2026 | $55.06 |
| Apr 10, 2026 | $53.98 |
| Apr 13, 2026 | $55.08 |
| Apr 14, 2026 | $56.16 |
| Apr 15, 2026 | $56.67 |
| Apr 16, 2026 | $56.37 |
| Apr 17, 2026 | $57.60 |
| Apr 20, 2026 | $56.76 |
| Apr 21, 2026 | $55.87 |
| Apr 22, 2026 | $56.21 |
| Apr 23, 2026 | $54.59 |
| Apr 24, 2026 | $54.41 |
| Apr 27, 2026 | $54.26 |
| Apr 28, 2026 | $53.54 |
| Apr 29, 2026 | $52.60 |
| Apr 30, 2026 | $53.61 |
| May 1, 2026 | $53.53 |
| May 4, 2026 | $55.19 |
| May 5, 2026 | $55.29 |
| May 6, 2026 | $56.38 |
| May 7, 2026 | $55.21 |
| May 8, 2026 | $55.52 |
| May 11, 2026 | $55.27 |
| May 12, 2026 | $55.14 |
| May 13, 2026 | $55.72 |
| May 14, 2026 | $55.11 |
| May 15, 2026 | $53.39 |
| May 18, 2026 | $51.56 |
| May 19, 2026 | $50.92 |
| May 20, 2026 | $52.83 |
| May 21, 2026 | $53.80 |
| May 22, 2026 | $53.30 |
| May 26, 2026 | $53.55 |
| May 27, 2026 | $53.82 |
| May 28, 2026 | $54.21 |
| May 29, 2026 | $54.44 |
| Jun 1, 2026 | $52.81 |
| Jun 2, 2026 | $50.31 |
| Jun 3, 2026 | $51.02 |
| Jun 4, 2026 | $52.22 |
| Jun 5, 2026 | $50.52 |
| Jun 8, 2026 | $50.34 |
| Jun 9, 2026 | $51.50 |
| Jun 10, 2026 | $50.52 |
| Jun 11, 2026 | $52.09 |
| Jun 12, 2026 | $52.76 |
| Jun 15, 2026 | $53.50 |
| Jun 16, 2026 | $53.26 |
| Jun 17, 2026 | $54.25 |
| Jun 18, 2026 | $55.11 |
| Jun 22, 2026 | $58.66 |
| Jun 23, 2026 | $59.14 |
| Jun 24, 2026 | $60.84 |
| Jun 25, 2026 | $61.37 |
| Jun 26, 2026 | $63.25 |
| Jun 29, 2026 | $64.59 |
| Jun 30, 2026 | $64.65 |
| Jul 1, 2026 | $63.35 |
| Jul 2, 2026 | $64.90 |
| Jul 6, 2026 | $64.84 |
| Jul 7, 2026 | $67.84 |
| Jul 8, 2026 | $68.31 |
| Jul 9, 2026 | $68.94 |
| Jul 10, 2026 | $67.22 |
| Jul 13, 2026 | $65.33 |
| Jul 14, 2026 | $65.29 |
| Jul 15, 2026 | $65.53 |
| Jul 16, 2026 | $63.44 |
| Jul 17, 2026 | $65.20 |
| Jul 20, 2026 | $63.60 |
| Jul 21, 2026 | $64.98 |
| Jul 22, 2026 | $64.10 |
| Jul 23, 2026 | $64.33 |
| Jul 24, 2026 | $63.77 |
| Jul 27, 2026 | $64.48 |
| Jul 28, 2026 | $63.52 |
| Jul 29, 2026 | $63.14 |
| Jul 30, 2026 | $65.20 |
| Jul 31, 2026 | $63.36 |
| Aug 3, 2026 | $63.53 |
| Aug 4, 2026 | $65.58 |
| Aug 5, 2026 | $66.29 |
| Aug 6, 2026 | $67.20 |
| Aug 7, 2026 | $67.61 |
| Aug 10, 2026 | $67.12 |
| Aug 11, 2026 | $67.10 |
| Aug 12, 2026 | $67.77 |
| Aug 13, 2026 | $66.92 |
| Aug 14, 2026 | $67.28 |
| Aug 17, 2026 | $67.82 |
| Aug 18, 2026 | $69.09 |
| Aug 19, 2026 | $70.79 |
| Aug 20, 2026 | $68.56 |
| Aug 21, 2026 | $69.11 |
| Aug 24, 2026 | $68.64 |
| Aug 25, 2026 | $70.33 |
| Aug 26, 2026 | $69.66 |
| Aug 27, 2026 | $69.51 |
| Aug 28, 2026 | $67.09 |
| Aug 31, 2026 | $66.82 |
| Sep 1, 2026 | $66.86 |
| Sep 2, 2026 | $67.89 |
| Sep 3, 2026 | $67.31 |
| Sep 4, 2026 | $67.66 |
| Sep 8, 2026 | $66.82 |
| Sep 9, 2026 | $65.20 |
| Sep 10, 2026 | $63.80 |
| Sep 11, 2026 | $63.29 |
| Sep 14, 2026 | $63.71 |
| Sep 15, 2026 | $62.54 |
| Sep 16, 2026 | $62.39 |
| Sep 17, 2026 | $63.73 |
| Sep 18, 2026 | $62.20 |
| Sep 21, 2026 | $62.38 |
| Sep 22, 2026 | $63.35 |
| Sep 23, 2026 | $59.85 |
| Sep 24, 2026 | $58.55 |
| Sep 25, 2026 | $57.56 |
| Sep 28, 2026 | $57.93 |
| Sep 29, 2026 | $57.94 |
| Sep 30, 2026 | $58.30 |
| Oct 1, 2026 | $56.64 |
| Oct 2, 2026 | $56.15 |
| Oct 5, 2026 | $56.26 |
| Oct 6, 2026 | $54.38 |
| Oct 7, 2026 | $54.13 |
| Oct 8, 2026 | $53.95 |
| Oct 9, 2026 | $55.04 |
| Oct 12, 2026 | $53.85 |
| Oct 13, 2026 | $51.64 |
| Oct 14, 2026 | $51.20 |
| Oct 15, 2026 | $52.22 |
| Oct 16, 2026 | $50.12 |
| Oct 19, 2026 | $52.11 |
| Oct 20, 2026 | $54.81 |
| Oct 21, 2026 | $54.57 |
| Oct 22, 2026 | $54.55 |
The desk’s read
Recent fund-flow records are unavailable, while the price has returned +6.5% so far this year. At 0.50% a year it is not the cheapest way in — IWM has a reported fee of 0.19%.
COMPOSED FROM THE FUND’S OWN DAILY RECORDS · UPDATED WITH EACH REFRESH
$114Massets under management
0.50%expense ratio · $50 per $10,000 a year
—net flow, trailing month
41Kavg daily volume, 30 days
95holdings · US-domiciled
2014listed December 30, 2014 · beta 1.04
Sector weights
- Healthcare100%
- Health Technology97.84%
- Other4.16%
- Health Services2.19%
- Mutual fund0.07%
Source: Portfolio composition, latest disclosure
Show as table
| Item | Value (%) |
|---|---|
| Healthcare | 100% |
| Health Technology | 97.84% |
| Other | 4.16% |
| Health Services | 2.19% |
| Mutual fund | 0.07% |
Country weights
- United States84.79%
- Netherlands4.21%
- United Kingdom3%
- Switzerland2.26%
- Canada2.18%
- France1.54%
- China1.21%
- Belgium1.19%
Source: Portfolio composition, latest disclosure
Show as table
| Item | Value (%) |
|---|---|
| United States | 84.79% |
| Netherlands | 4.21% |
| United Kingdom | 3% |
| Switzerland | 2.26% |
| Canada | 2.18% |
| France | 1.54% |
| China | 1.21% |
| Belgium | 1.19% |
Performance
| 1 week | +8.8% |
| 1 month | -13.9% |
| 3 months | -14.9% |
| 6 months | -3.9% |
| YTD | +6.5% |
| 1 year | +29.8% |
| 3 years | — |
PRICE RETURN, DISTRIBUTIONS NOT REINVESTED
Net flows
| 1 week | — |
| 1 month | — |
| 3 months | — |
| YTD | — |
| 1 year | — |
CREATION/REDEMPTION DOLLARS, DAILY RECORDS
The risk read
41%realized volatility, 30 days (annualized)
32%realized volatility, 1 year
-29.2%deepest fall from a peak, 1 year
-22.9%latest close versus that peak
VOLATILITY & DRAWDOWN FROM THE DAILY TAPE · CONCENTRATION FROM THE LATEST DISCLOSED BOOK
Options tape
—calls · latest snapshot
—puts · latest snapshot
—put/call ratio
13Kshares traded
The case against SBIO
Due diligence cuts both ways. These funds sit on the same shelf and beat SBIO on at least one dimension that matters — the fee, the asset base, or where the money is going.
| Fund | Fee | Assets | Flow, 1M | The case | |
|---|---|---|---|---|---|
| SPDW SPDR Portfolio Developed World ex-US ETF | 0.03% | $41.2B | +$609M | -47bp on fee · 361× the assets · +$609M in over the month | Head-to-head |
| SPMD State Street SPDR Portfolio S&P 400 Mid Cap ETF | 0.03% | $18.4B | +$199M | -47bp on fee · 161× the assets · +$199M in over the month | Head-to-head |
| IDEV iShares Core MSCI International Developed Markets ETF | 0.04% | $32.4B | +$497M | -46bp on fee · 284× the assets · +$497M in over the month | Head-to-head |
| IGIB iShares 5-10 Year Investment Grade Corporate Bond ETF | 0.04% | $18.6B | +$412M | -46bp on fee · 163× the assets · +$412M in over the month | Head-to-head |
| IEFA iShares Core MSCI EAFE ETF | 0.07% | $191B | +$817M | -43bp on fee · 1674× the assets · +$817M in over the month | Head-to-head |