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Friday, October 2, 2026The Morning Brief →Sign in
IBRNISharesINDEX

iShares Neuroscience and Healthcare ETF

$32.87-1.20% vs prior close
274152-WK

Price through Sep 30 · Flows through Sep 29. Figures use the latest available records, not a live quote. Fund details retrieved Oct 1. Holdings snapshot retrieved Oct 1.

The fund will invest at least 80% of its assets in the component securities of its index and in investments that have economic characteristics that are substantially identical to the component securities of its index and may invest up to 20% of its assets in certain futures, options and swap contracts, cash and cash equivalents as well as in securities not included in the index, but which BFA believes will help the fund track the index. It is non-diversified.

Price & daily flows
37.733.829.832.87DAILY NET FLOWOct 1Jan 30Jun 1Oct 1

SOURCE: MARKET TAPE & DAILY CREATION/REDEMPTION RECORDS · 3Y SHOWN · NET +$790K OVER THIS RANGE

The desk’s read

Money is leaving — −$60K in net outflows over the past month, while the price has returned +1.7% so far this year. At 0.47% a year it is not the cheapest way in — FDHT has a reported fee of 0.39%.

COMPOSED FROM THE FUND’S OWN DAILY RECORDS · UPDATED WITH EACH REFRESH

$6640.17Tassets under management
0.47%expense ratio · $47 per $10,000 a year
−$60Knet flow, trailing month
2Kavg daily volume, 30 days
54holdings
2022listed August 23, 2022 · beta 1.03
The book at a glance
NEU+2.6%BIIB-1.4%EWTX-0.3%PTCT-1.0%ARGX-2.4%NBIX-0.8%ALKS+0.0%SRRK-4.5%DNTH+0.3%PRAX-1.5%SUPN-2.0%ACAD-1.3%AXGN-4.8%XENE+4.7%DYN-1.8%SRPT-3.6%BHVN-1.6%TSHA-2.7%IART-1.2%LBRX-2.9%RAPP-2.3%ANRO-0.9%ANNX-2.6%CBLL-3.2%SLDB-3.5%BWAY-4.5%OVID-2.4%DSGNNGNE

CELL SIZE IS PORTFOLIO WEIGHT · COLOR IS THE CHANGE IN THE LATEST AVAILABLE SNAPSHOT · TOP 40 POSITIONS

HoldingsDownload CSV
#HoldingWeightPriceDay52-wk
1NEUNEWMARKET2.28%$921.14+2.6%
2BIIBBIOGEN4.78%$222.82-1.4%
3EWTXEDGEWISE THERAPEUTICS4.22%$40.48-0.3%
4PTCTPTC THERAPEUTICS4.35%$64.13-1.0%
5ARGXARGENX SE4.37%$936.00-2.4%
6NBIXNEUROCRINE BIOSCIENCES4.13%$140.71-0.8%
7ALKSALKERMES4.11%$40.54+0.0%
8SRRKSCHOLAR ROCK HOLDING4.00%$46.16-4.5%
9DNTHMAGENTA THERAPEUTICS INC3.74%$88.32+0.3%
10PRAXPRAXIS PRECISION MEDICINES3.70%$286.91-1.5%
11SUPNSUPERNUS PHARMACEUTICALS3.51%$42.18-2.0%
12ACADACADIA PHARMACEUTICALS3.35%$19.89-1.3%
13AXGNAXOGEN3.27%$39.92-4.8%
14XENEXENON PHARMACEUTICALS2.90%$38.93+4.7%
15DYNDYNE THERAPEUTICS3.10%$15.82-1.8%

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Sector weights
Health Care98.8%
Information Technology1.09%
Cash and/or Derivatives0.1%
PORTFOLIO COMPOSITION, LATEST DISCLOSURE
Country weights
United States75.64%
Belgium4.37%
Korea (South)3.18%
Sweden3%
Denmark2.61%
Australia2.31%
Switzerland2.08%
Japan1.92%
PORTFOLIO COMPOSITION, LATEST DISCLOSURE
Performance
1 week-1.4%
1 month-15.6%
3 months-14.2%
6 months+6.8%
YTD+1.7%
1 year+22.3%
3 years—

PRICE RETURN, DISTRIBUTIONS NOT REINVESTED

Net flows
1 week−$7K
1 month−$60K
3 months+$2M
YTD+$2M
1 year+$2M

CREATION/REDEMPTION DOLLARS, DAILY RECORDS

Monthly net flows
SepOctNovDecJanFebMarAprMayJulAugSep
DAILY CREATION/REDEMPTION RECORDS, TRAILING TWELVE MONTHS
The risk read
25%realized volatility, 30 days (annualized)
26%realized volatility, 1 year
-19.2%deepest fall from a peak, 1 year
-19.2%latest close versus that peak

The top holding is 4.8% of the book; the top ten carry 41%. Spread across 75+ names, it behaves like roughly 35 equally-weighted positions.

VOLATILITY & DRAWDOWN FROM THE DAILY TAPE · CONCENTRATION FROM THE LATEST DISCLOSED BOOK

Options tape
—calls · latest snapshot
—puts · latest snapshot
—put/call ratio
1Kshares traded
Most-traded holdings, options premiumBullishBearish
DYN DYNE THERAPEUTICS$8M$2M
AXGN AXOGEN$420,051$486,325
ARGX ARGENX SE$133,617$645,186
PTCT PTC THERAPEUTICS$313,359$425,676
CAPR CAPRICOR THERAPEUTICS$209,132$474,625

TODAY’S OPTIONS PREMIUM IN THE FUND’S UNDERLYING NAMES

The case against IBRN

Due diligence cuts both ways. These funds sit on the same shelf and beat IBRN on at least one dimension that matters — the fee, the asset base, or where the money is going.

FundFeeAssetsFlow, 1MThe case
SPDW State Street SPDR Portfolio Developed World ex-US ETF0.03%$41.5B+$286M-44bp on fee · +$286M in over the monthHead-to-head
SPMD State Street SPDR Portfolio S&P 400 Mid Cap ETF0.03%$18.2B+$199M-44bp on fee · +$199M in over the monthHead-to-head
IDEV iShares Core MSCI International Developed Markets ETF0.04%$32.9B+$497M-43bp on fee · +$497M in over the monthHead-to-head
IGSB iShares 1-5 Year Investment Grade Corporate Bond ETF0.04%$23.7B+$575M-43bp on fee · +$575M in over the monthHead-to-head
IGIB iShares 5-10 Year Investment Grade Corporate Bond ETF0.04%$18.6B+$412M-43bp on fee · +$412M in over the monthHead-to-head
Sign in to save this to The RecordA timestamped copy for the file — documentation, not advice.
InstrumentsHarvest substitutesTrade cost at $1MClient tearsheetStress this fund
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